The Mitochondrial Permeability Transition Pore Regulates Endothelial Bioenergetics and Angiogenesis
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چکیده
منابع مشابه
The mitochondrial permeability transition pore regulates endothelial bioenergetics and angiogenesis.
RATIONALE The mitochondrial permeability transition pore is a well-known initiator of cell death that is increasingly recognized as a physiological modulator of cellular metabolism. OBJECTIVE We sought to identify how the genetic deletion of a key regulatory subunit of the mitochondrial permeability transition pore, cyclophilin D (CypD), influenced endothelial metabolism and intracellular sig...
متن کاملMitochondrial Permeability Transition Pore Regulates Endothelial Bioenergetics and Angiogenesis
Subject codes: [95] Endothelium/vascular type [129] Angiogenesis [140] Energy metabolism [145] Genetically altered mice ABSTRACT Rationale: The mitochondrial permeability transition pore (mPTP) is a well-known initiator of cell death that is increasingly recognized as a physiological modulator of cellular metabolism. Objective: We sought to identify how the genetic deletion of a key regulatory ...
متن کاملThe mitochondrial permeability transition pore.
This chapter reviews recent advances in the identification of the structural elements of the permeability transition pore. The discovery that cyclosporin A (CsA) inhibits the pore proved instrumental. Various approaches indicate that CsA blocks the pore by binding to cyclophilin (CyP)-D. In particular, covalent labelling of CyP-D in situ by a photoactive CsA derivative has shown that pore ligan...
متن کاملMitochondrial permeability transition pore and postconditioning.
Postconditioning has recently been described as a powerful cardioprotection that prevents lethal reperfusion injury. Growing evidence suggests that mitochondrial permeability transition may be a key event in postconditioning. This proposition arises from the complementary observations that: (1) conditions for the mitochondrial permeability transition pore (mPTP) opening are built up during earl...
متن کاملMitochondrial permeability transition pore: an enigmatic gatekeeper
Mitochondrial permeability transition pore (MPTP) is a transient structure formed in the inner mitochondrial membrane (IMM) upon oxidative challenge of the organelle. The transition is a Ca 2+ -dependent increase of permeability of IMM leading to loss of transmembrane potential (∆ψm), mitochondrial swelling and, finally, rupture of outer mitochondrial membrane leading to release of factors caus...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2015
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.116.304881